As global warming leads to more frequent droughts and heatwaves, the internal processes of staple crops are being disrupted, particularly photosynthesis, which is crucial for plant growth. Berkley Walker and his team at Michigan State University are exploring ways to engineer crops to withstand higher temperatures by focusing on the enzyme glycerate kinase (GLYK), which plays a key role in photosynthesis. Using AlphaFold to predict the 3D structure of GLYK, they discovered that high temperatures cause certain flexible loops in the enzyme to destabilize. By replacing these unstable loops with more rigid ones from heat-tolerant algae, they created hybrid enzymes that remain stable at temperatures up to 65°C, potentially leading to more resilient crops. This matters because enhancing crop resilience is essential for maintaining food security in the face of climate change.
